The Luna expansion for Galileo Galilei introduces the Moon as a key area for discovery, with new scoring objectives focused on lunar exploration and astronomical breakthroughs. The expansion adds a new Inquisition area with Grand Inquisitors, creating both risks and rewards. Players must navigate these challenges to make significant progress in the game.

It also introduces four historical figures, like Maria Cunitz and Isaac Newton, each bringing unique abilities and strategic advantages. Their inclusion adds depth and variety to gameplay, allowing for new tactical approaches and altering the course of scientific discovery.

Ultimately, Luna deepens the strategic landscape, presenting players with the choice of whether the heavens will offer them glory, or bring the wrath of the Inquisition.