In VS System 2PCG, players choose a main character, build a deck with exactly sixty cards, and attempt to KO the other player's main character in a game of superhero battles.

VS System 2PCG: Brotherhood of Mutants introduces 55 new cards that focus on the rival of the X-Men! This set includes Main Characters, Supporting Characters, Plot Twists, and Locations. VS System 2PCG: Brotherhood of Mutants can be combined with any other VS System 2PCG sets. A single box contains a full play-set of all cards.

This is not a stand-alone game. A copy of Vs. System 2PCG: The Marvel Battles is required to play.