In Vs System 2PCG, players choose a main character, build a deck with exactly sixty cards, and attempt to KO the other player's main character in a game of superhero battles.

Vs System 2PCG: Deadpool & Friends showcases 55 new cards that are Deadpool and Deadpool-related. Like his friends. Including Main Characters, Supporting Characters, Plot Twists, and Locations. Vs System 2PCG: Deadpool & Friends can be combined with any other Vs System 2PCG sets.

This is not a stand-alone game.